Some famous celebrities have made their homes in or made prominent visits to Anacortes, including:
- Jake Anderson--star of the Discovery Channel's "Deadliest Catch" (IMDB)
- Bobo--a pet gorilla that lived in Anacortes in the 1950s
- Craig Bartlett--creator of the Nickelodeon series "Hey Arnold!"
- Sherean Kesheb--appeared on "Naked and Afraid"
- Burl Ives
- Devan Long--IMDB
- Rien Long--former NFL player
- Sean McCool--appeared on "Naked and Afraid"
- William Cameron ("Willie") McCool--pilot of the Space Shuttle Columbia on the STS-107 mission