Royal Samuel Copeland (1868 - 1938) was mayor of Ann Arbor from 1901 to 1903. He graduated from the Homeopathic Medical College of the University of Michigan in 1889.

In 1900, Copeland's offices were at 317 S. State St. James J. Quarry ran the Campus Drug Store, and he shared offices with D W Myers, C B Kinyon, W B Hinsdale, and W A Dewey, all physicians.

Copeland moved to New York City in 1908 to assume the deanship of the New York Homeopathic Medical College. In 1924 he was elected as a Democratic Senator of the state of New York, a position which he served in until his death in 1938.

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Professor of homoeopathic medicine at University of Michigan, mayor of Ann Arbor, Michigan, dean of the New York Homeopathic Medical College and director of Flower Hospital, New York City Commissioner of Public Health, and Democratic U. S. Senator from New York, 1923-1938. Personal and medical correspondence, speeches, scrapbooks containing food and health articles, photographs, and other papers concerning his medical and political interests. Correspondents include: Calvin Coolidge, Herbert Hoover, Eleanor Roosevelt, Franklin D. Roosevelt, and Alfred E. Smith.