The Cincinnati Zoo and Botanical Garden  It opened in 1875 and is the Second-Oldest zoo right behind the Philadelphia. The Reptile House is the oldest zoo building in the United States, dating from 1875. The land area of the zoo is 75 acres.

The Cincinnati Zoo is also home to the 2016 gorilla shooting incident, where a young boy fell into the gorilla exhibit and was "dragged around" by the at home gorilla called Harambe who was later fatally shot to save the child.