Depot Street runs northwest from Bloomingdale Avenue opposite Church Street to Union Depot. It was called Railroad Street in 1895, but that name was retired by October of 1899 in favor of Depot Street, which is still used today. 1
| Old Address | Post-911 Address | Building Name | Cure Evidence/Notes |
| 10 Depot Street | 10 Depot Street | ||
| 12 Depot Street | 15 Depot Street |
 12 Depot Street |
TBSWC |
| 14 Depot Street | TBSWC | ||
| 23 Depot Street | 24 Depot Street |
 23 Depot Street |
|
| 28 Depot Street |
 Express Office |
||
| 16 Depot Street | 33 Depot Street |
 Depot Street Plaza |
(formerly Branch & Callanan) |
| 19 Depot Street | 42 Depot Street |
 Union Depot |
Footnotes
1. Sanborn Map Company, Saranac Lake maps of 1895 & 1899.
