Film
* Eva Angelina - Adult film actress, graduated from Foothill High School.
* John P. Bell - US Army Combat Medic, featured in the 2010 HDNet documentary Baker Boys: Inside The Surge, graduated from Tustin High School
* Cuba Gooding Jr. - Actor, best known for portraying the character 'Rod Tidwell' in the movie Jerry Maguire, attended Tustin High School, but graduated from John F. Kennedy High School in Granada Hills, CA
* Rachel Kimsey - Actress, best known for portraying the character 'Mackenzie Browning' on the soap opera The Young and the Restless, graduated from Tustin High School
* Matthew Lillard - Actor, best known for portraying the character 'Stu Macher' in the movie Scream graduated from Foothill High School
* 'John Locke' - a fictional character played by Terry O'Quinn on the television show Lost is from Tustin.
* Amberlina (Amberlina Lynn) - Adult film actress, graduated from Tustin High School
Athletes
* Mike Champion-Former MLB player with the San Diego Padres. Mike played 2nd base.
* Sam Baker - current NFL offensive tackle for the Atlanta Falcons, graduated from Tustin High School
* James Beaumont "Beau" Bell - current linebacker for the Omaha Nighthawks of the United Football League and former NFL linebacker for the Cleveland Browns, graduated from Tustin High School
* Heath Bell - current MLB all-star closing pitcher for the San Diego Padres, graduated from Tustin High School
* Milorad Čavić - Three-time Olympic swimmer for Serbia, lived in Tustin
* Chris Chester - current NFL offensive lineman for the Baltimore Ravens, graduated from Tustin High School
* DeShaun Foster - former NFL running back for the Carolina Panthers and San Francisco 49ers, graduated from Tustin High School
* Alfonso Gómez - current professional welterweight boxer and former contestant on season 1 of The Contender, lived in Tustin
* Doug Gottlieb - current ESPN analyst and host of The Doug Gottlieb Show on ESPN Radio, and former NCAA basketball point guard for the University of Notre Dame and Oklahoma State University, graduated from Tustin High School
* Mark Grace - former MLB all-star first baseman for the Chicago Cubs and Arizona Diamondbacks, graduated from Tustin High School
* Shawn Green - former MLB all-star outfielder for the Toronto Blue Jays, Los Angeles Dodgers, Arizona Diamondbacks, and New York Mets, graduated from Tustin High School
* Billy Hart - current Minor League Baseball outfielder for the Corpus Christi Hooks, attended Foothill High School
* Rex Hudler - former MLB utility player for the New York Yankees, Baltimore Orioles, Montreal Expos, St. Louis Cardinals, California Angels, and Philadelphia Phillies, as well as utility player for the Tokyo Yakult Swallows of the Nippon Professional Baseball league, and former broadcaster for the Los Angeles Angels of Anaheim, was born in Tustin
* Phil Hughes - current MLB starting pitcher for the New York Yankees, graduated from Foothill High School
* Matt McCoy - current NFL linebacker for the Seattle Seahawks, formerly of the Philadelphia Eagles, New Orleans Saints, and Tampa Bay Buccaneers, graduated from Tustin High School
* Frostee Rucker - current NFL defensive end of the Cincinnati Bengals, graduated from Tustin High School
* Richard Umphrey III - former NFL center for the New York Giants and the San Diego Chargers, graduated from Tustin High School
* Anthony Wilkerson- currently a running back at Stanford University, Graduated from Tustin High
Other
* Corky King (Claude Rex Nowell) - founder of the religion Summum, graduated from Tustin High School
* Mary Kay Letourneau - daughter of US Representative John G. Schmitz and former schoolteacher, internationally publicized for being convicted in 1997 for statutory second degree rape of a 12 year-old student, lived in Tustin
