5th Street in Marysville runs between A Street and the 5th Street Bridge. At the 5th Street Bridge, it becomes Bridge Street in Yuba City.

From west to east, significant places on 5th Street include Beckwourth Riverfront Park Complex, The Castle, Cotton's Cowboy Corral, Hotel Marysville, Matthew's Music, and Veterans Park.

In 1858, the California State Fair was held in Marysville, in the area bounded by 5th Street, 6th Street, B Street, and C Street.