East 22nd Street in Marysville is a public street that runs between Ramirez Street and Highway 20. The entire street goes by the name of "East" 22nd Street because the portions of all numbered streets that extend into East Marysville are called "East," and East 22nd Street does not extend outside of East Marysville.

From west to east, significant places on East 22nd Street include Triplett Park and Circle A Food Mart.