Larkin Road runs northeast from Eager Road in Nuestro to Highway 162 near Oroville. Along the way, it passes through Encinal, Live Oak, and East Gridley.

From south to north, significant places on Larkin Road include Johnson Water Softener Repair, Encinal Elementary School, Bihlman Butte Rock, Live Oak Manor, Butte View Estates, Buttes Insurance, Bruce M. Pope, D.D.S., and Oak Tree Park.