Spenceville Road is a public road that is divided into two slightly disconnected segments.

The southwestern segment, which overlaps with Camp Beale Highway for the entire length of the segment, runs between the intersection of Main Street and Olive Street in Wheatland and East Garryana Drive on Beale Air Force Base. On the way, it passes through Horstville.

The northeastern segment, which begins not far from where the southwestern segment ended, runs between Tyburn Drive on Beale Air Force Base and Penn Valley Drive in Penn Valley. On the way, it passes through Spenceville State Wildlife Area.

Significant places on Spenceville Road include Bear River Veterinary Clinic, Lone Tree Elementary School, and Waldo Junction.