Given the city's rich history and diversity, it isn't surprising that there are roleplaying games set in San Francisco. Like many depictions of the city in fiction, they vary wildly by genre and tone.

Call of Cthulhu by Chaosium has a resource book for the area during the 1920's in the world of HP Lovecraft. Full of arcane relics and a central shipping and travel port to the Pacific, the city in "Secrets of San Francisco" is a dangerous occult location full of dark gods and idols.