Franklin Avenue is known as Franklin Road west of Highway 99. It runs between Garden Highway in southern Yuba City and Tarke Road in eastern Meridian, and forms the border betwen Yuba City and South Yuba City. It is one of only six roads that cross the Sutter Bypass; the others are Highway 20, Highway 113, Hughes Road, Kirkville Road, and Pass Road.

From east to west, significant places include the Yuba-Sutter Fairgrounds on Franklin Avenue and Panaderia Flores and Bill's Market and Deli on Franklin Road.