Cross Street is one of the main arteries of Ypsilanti. It is one-way, east-to-west, from Huron Street to the Ypsilanti Water Tower, hosting the campus area business strips; further east, it serves as the main street for Depot Town, then runs through residential neighborhoods until converging with Michigan Avenue a few miles east. Further west, after crossing Washtenaw Avenue in an "x", it becomes the main arterial for the Normal Park neighborhood and provides access to Ypsilanti High School, Estabrook Elementary School, and West Middle School, before turning into Packard Road around Hewitt Road.

• 729 W. Cross - Unnamed O'Neal Construction project, as of February 2011.
  • Was Ted's Campus Drugs and Art Attack
• 705 W. Cross - The Wurst Bar
  • Was Theo Door's Bar
• 701 W. Cross - Tower Inn Cafe

• EMU Counseling Center
• Pease Auditorium

• Jimmy Johns
• Barnes and Barnes offices
• 533 W. Cross - Double Eagle Coney Island
• Thoroughbred Styles
• La Fiesta Mexicana
• Cross Street Books
• 517 W. Cross - Crossroads Bar & Grill
  • was Screamin' Eagle Bar and Grill (c. 2008-2009)
  • was Andrew's (c. 2006-2008)
  • was D'Angoras (c. 2005-2006)
  • was Magazine Rack (c. 2005)
• 515 W. Cross - medical marijuana clinic
  • was Wings Wings Wings (c. 2008-2009)
• 511 W. Cross - vacant
  • was Cross Street Station (c. 1990s)
• 505 W. Cross - College Inn (moved from N. Huron)
  • was Wast Coast Sandwiches (c. 2008-2009)
  • was Town Cafe (c. 2007-2008)
  • was Taqueria Jalisco Mexican (c. 2006)
• Tom's Party Store
• Eagle's Market
• Two (count 'em) tanning salons

• Golden Wall
• St. John the Baptist Catholic Church
• Madonna Park
• City Printing

• 317 W. The Ugly Mug
• Maggie's Organics
• 301 W. Cross - Vacant
  • was Toarmina's Pizza (2 different owners, c. 2009-2010)
  • was Cardozia's Pizza (c. 2008)
  • was Tic Toc Pizza (c. 2007)
  • was Leonardo's Pizza (c. 2006)
  • was a very, very large number of pizza places and vacant former pizza places.
  • was one of the first Domino's Pizza locations.

• 210 W. Cross Street Village

• Michigan Firehouse Museum

• Riverside Park

• The Tridge!
• Frog Island Park

Then into Depot Town, with,

• Aubree's
• Cady's Bar and Grill
• Stick's
• Sidetrack
• 56 E.: Frenchie's
• 19 E.: Fantasy Attic costumes
• Cafe Luwak
• Dreamland Theater
• Quinn's Essentials
• Cheeky Monkey Bears and Gifts
• Ypsilanti Depot

• Railroad tracks
• Auto museum
• Thompson Building

eventually ends at Michigan Avenue, near Value World.