The Berkeley House survived this fire on January 1, 1925, though it lost its top floor in the renovation that followed. The building was destroyed by the fire of January 10, 1981. Fire has played a major role in the history of the Saranac Lake area.  Many houses, and most of the area's hotels have burned, some more than once, and forest fires have transformed the landscape.

From the Adirondack Enterprise, January 16, 1925:

"Fire Escapes to be Required for Sanatoria Here State Public Health Law Compliance Demanded by Veterans Bureau Health Board Acts Survey Started to Make Enforcement Uniform on 3-Story Houses Cottage sanatoria in Saranac Lake of 3 or more stories height will be required to construct iron stairway fire escapes under concurrent action being taken by local health authorities, county officers and the U.S. Veterans Bureau." [Cancellation of contracts following failure to comply . . .] "In order to make enforcement uniform throughout the village, the board of health is to make a survey of all nursing cottages, boarding houses and other buildings housing tuberculosis patients." . . .

Listed here are some of the properties damaged or destroyed by fire over the years.